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. 2011 Jun 30;12:64. doi: 10.1186/1471-2202-12-64

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Copyright ©2011 Liu et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Increased infarct size and reduced hemisphere volume in injured nes-igf1r^-/Wtmice. Paraffin-embedded brains were serially sectioned and stereologically analyzed as described in Methods. A. Representative Cresyl Violet staining of brain sections from a nes-igf1r^-/Wtmouse (KO) and its littermate control (Contl) at 3 and 7 DAI, respectively. B. Infarct size. The area of infarct in the ipsilateral hemisphere is expressed as a percentage of the ipsilateral hemisphere area. Each dot represents the value from an individual mouse. Values represent mean ± SE from 6 - 10 brains in each group. C. Quantification of hemisphere and hippocampus volume. Hemisphere and hippocampus volume is expressed as percentage of contralateral counterparts. Values represent mean ± SE from 5 - 8 brains in each group. *, p < 0.05; **, p < 0.01, compared to control mice.