Table 3.
Comparative positional analysis of identified QTL with serum lipid QTL in humans and mice and the putative candidate genes located on the QTL regions
| SSC | Traits | POS (cM) | PCB at peak | HCHR | QTL in human | HCBP | Putative candidate genes | Mouse strain | QTL mouse peak |
|---|---|---|---|---|---|---|---|---|---|
| 1 | CT* | 80 | 1q1.3 - 1.4 | 18q21 15q21-22 |
CT | 18q21 [51] | LIPC [52], LIPG [53], ACAA2 [54], STARD6 [55] | (B6 × C3H) F2 (B6 × DBA/2) F2 (B6 × CAST/2) F2 (B6 × C3H) F2 |
18-40cM 18-46cM 18-47cM 18-48cM |
| 1 | HDL/LDL** | 87 | 1q1.5-1.6 | HDL | 15q21 [56], 15q22 [57] | (B6 × 129) F2 | 2-90 cM | ||
| 1 | LDL*** | 82 | 1q1.3 - 1.4 | LDL-ApoB1 | 18q21.32 [58] | ||||
| 2 | TG | 205 | 2q2.8-2.9 | 5q23-31 | TG | 5 q21.3 -q32 [59] | STARD4 [60] | ||
| 2 | HDL*# | 118 | 2p1.2- 2q1.2 | 11q13 | HDL | 11q12-13 [31] | CILP, PBX4 | (MRL × SJL) F2 (B6 × C3H) F2 |
7-10 cM 7-19 cM |
| 3 | HDL* | 0 | 3p1.5-p1.4 | 7q11 | HDL TC |
7q11.23 [61] 7q11.23 [62] |
FABP1 | (NZB × SM) F2 NZO × (SJL × NZO) (B6 × CAST) F2 |
5-61.cM 5-69cM 5-72 CM |
| 4 | HDL/LDL* | 58 | 4q1.4-1.5 | 1q22-25 | HDL | 1q21-23 [63] 1q23-25 [64]; 1q24 [65], 1q25 [66] |
CYP7A1[67,68]; FABP5[69] |
(B6 × NZB11) F2 | 1-91 CM |
| 6 | CT* | 99 | 6q2.3 - 2.4 | 1p36.3-36.1 | LDL | 1q36.31 [63] 1q36.13 [70] |
NR1H2 WWOX [71] LDLRAP1 |
||
| 6 | TG* | 66 | 6q1.1 - 2.1 | 19q13 | LDL, TG |
19 q12 39 cM [72] 19q13.31 [51], [73] |
APOE [74]; ANGPTL3 | ||
| 7 | CT, LDL* | 70 | 7q1.4-71.5 | 15q24-28 | LDL | 15q26.1 [51] | STARD5 | ||
| 11 | TG*# | 28 | 11p1.1 -1.2 | 13q12 -24 | TG and HDL | 13q13 [75] | |||
| 12 | CT** | 36 | 12p1.3-q1.2 | 17q21-25 | CT/HDL | 17q24 [76] | WIPI1, | ||
| 12 | LDL* | 38 | LDL | 17q24.2 [65]; 17q25.3 [77] | THRA PEMT | ||||
| 13 | LDL* | 97 | 13q3.3 -3.5 | 3p31-21 | LDL | 3p25 [72] | PCYT1A [78]; B4GALT4 [79] | (C56BL/6JxDBA/2J) | 3-27cM [80] |
| 16 | HDL* | 81 | 16q1.4-2.1 | 5p14 -12 | HDL | 5p13.3 [81] 5p15.13 [82] |
(PERAxDBA/2) F2 (PERAxI) F2 |
11-28 cM 11-28 cM |
|
| 16 | HDL/LDL* | 47 | 16q1.3-1.4 | 5p14 -12 | LDL | 5p15.33 [64] | |||
| 17 | TG*# | 72 | 17q2.2-2.3 | 13q13 | TG and HDL | 13q13 [75] | ACSS, PLTP |
PCB, pig cytogenetic band; HCHR, human chromosome homologous regions; HCBP, human cytogenetic band.
Significance: Significance of the QTL: * significant on a chromosome-wide level with P < 0.05; ** significant on a experiment-wide level with P < 0.05; *** significant on a experiment-wide level with P < 0.01. Human homologous regions of the pig QTL were identified with the pig QTL database. # QTL with imprinting effect.