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. 2011 Jun 16;11:254. doi: 10.1186/1471-2407-11-254

Figure 4.

Figure 4

Specificity of barasertib-hQPA in AML cell lines in combination with ABC transporter modulators. A, Effect of 24 hours barasertib-hQPA exposure +/- 2.5 μg/ml CSA on pHH3 expression in OCI-AML3, OCI-AML3DNR and KG-1a cells (*p = 0.145/**p = 0.145) (analysed using paired samples t-test), +95% confidence interval) (i). Effect of 72 hours barasertib-hQPA exposure +/-2.5 μg/ml CSA on viable cell count (ii). B, Effect of 24 hours barasertib-hQPA exposure +/- 5 μM FTC on pHH3 expression in OCI-AML3 and OCI-AML6.2 cells (***p = 0.021) (i). Effect of 72 hours barasertib-hQPA exposure +/- 5 μM on viable cell count (ii). Columns/lines, mean of three experiments; bars, SD.