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. 2011 Jul 29;6(7):e21696. doi: 10.1371/journal.pone.0021696

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Yanhua Liang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Decreased Sharpin expression by shRNA interference or Loss of function of Sharpin^cpdm mutation resulted in NFκB activation. On the contrary, overexpression of Sharpin by flag tagged Sharpin has inhibition effect on NFκB activation.