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. 2011 Jul 29;6(7):e22209. doi: 10.1371/journal.pone.0022209

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Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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For telomeric heterochromatin assembly, it is necessary for nucleosomes to form an appropriately arrayed chromatin so that SIR complex can bind to the nucleosome stably and then deacetylate histones. The T122E mutation in the H2B C terminal tail may cause the formation of aberrantly condensed chromatin at telomere (perhaps through changes in electrostatic interactions) which may affect gene silencing.