Table 2. Differently expressed gene ontology categories in KBD vs. control.

Gene Ontology Category	Function	NESa	P-value
Up-regulated
APOPTOTIC_PROGRAM	Apoptosis	0.63	<10−3
INDUCTION_OF_APOPTOSIS_BY_EXTRACELLULAR_SIGNALS	Apoptosis	0.63	<10−3
ANTI_APOPTOSIS	Apoptosis	0.44	<10−3
PROGRAMMED_CELL_DEATH	Apoptosis	0.35	0.03
APOPTOSIS_GO	Apoptosis	0.35	0.03
NEGATIVE_REGULATION_OF_APOPTOSIS	Apoptosis	0.41	0.03
NEGATIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH	Apoptosis	0.41	0.03
REGULATION_OF_APOPTOSIS	Apoptosis	0.35	0.05
REGULATION_OF_PROGRAMMED_CELL_DEATH	Apoptosis	0.35	0.05
SKELETAL_DEVELOPMENT	Skeleton development	0.53	0.04
MITOCHONDRIAL_ENVELOPE	Mitochondrion related	0.53	0.03
OXIDOREDUCTASE_ACTIVITY_GO_0016616	Oxidation-reduction reaction related	0.34	0.05
OXIDOREDUCTASE_ACTIVITY__ACTING_ON_CH_OH_GROUP_OF_DONORS	Oxidation-reduction reaction related	0.34	0.05
CELLULAR_RESPIRATION	Aerobic and anaerobic respiration related	0.56	0.03
EXTRACELLULAR_REGION_PART	Extracellular environment	0.39	<10−3
EXTRACELLULAR_REGION	Extracellular environment	0.38	<10−3
EXTRACELLULAR_SPACE	Extracellular environment	0.35	0.05
PORE_COMPLEX	Membrane passage	0.48	0.03
POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY	Hydrolysis related	0.47	0.05
PHOSPHORIC_DIESTER_HYDROLASE_ACTIVITY	Phosphodiester hydrolysis related	0.54	0.03
PROTEIN_OLIGOMERIZATION	Protein polymer production	0.57	<10−3
COFACTOR_METABOLIC_PROCESS	Cofactor related	0.52	0.04
ANGIOGENESIS	VEGFA related	0.45	0.03
Down-regulated
HYDROLASE_ACTIVITY__HYDROLYZING_O_GLYCOSYL_COMPOUNDS	O-glycosyl hydrolysis	−0.60	<10−3

^adenotes the normalized enrichment score calculated by GSEA.