Table 3. Selected pathways significantly up-regulated in KBD vs. control.
| Pathway | Description | NESa | P-value |
| REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in intrinsic pathway for apoptosis | 0.62 | <10−3 |
| FRIDMAN_SENESCENCE_UP | Genes up-regulated in senescent cells. | 0.54 | <10−3 |
| REACTOME_APOPTOSIS | Genes involved in apoptosis | 0.42 | <10−3 |
| FRIDMAN_IMMORTALIZATION_DN | Genes down-regulated in immortalized cell lines. | 0.64 | <10−3 |
| ALCALA_APOPTOSIS | Genes able to induce cell death in an expression cDNA library screen. | 0.45 | <10−3 |
| BIOCARTA_CERAMIDE_PATHWAY | Ceramide signaling pathway | 0.67 | <10−3 |
| HARRIS_HYPOXIA | Genes known to be induced by hypoxia | 0.62 | <10−3 |
| SEMENZA_HIF1_TARGETS | Genes that are transcriptionally regulated by HIF1A | 0.77 | <10−3 |
| WINTER_HYPOXIA_METAGENE | Genes regulated by hypoxia, based on literature searches. | 0.51 | <10−3 |
| ELVIDGE_HYPOXIA_BY_DMOG_UP | Genes up-regulated in MCF7 cells (breast cancer) treated with hypoxia mimetic DMOG | 0.59 | 0.027 |
| LEONARD_HYPOXIA | Genes up-regulated in HK-2 cells kidney tubular epithelium under hypoxia and down-regulated on re-oxygenation | 0.59 | <10−3 |
| KEGG_PEROXISOME | Peroxisome | 0.49 | <10−3 |
| GALLUZZI_PERMEABILIZE_MITOCHONDRIA | Proteins that permeabilize mitochondria. | 0.48 | <10−3 |
| BIOCARTA_AT1R_PATHWAY | Angiotensin II mediated activation of JNK pathway via Pyk2 dependent signaling | 0.59 | <10−3 |
a
denotes the normalized enrichment score calculated by GSEA.