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. 2011 Jul 29;6(7):e23060. doi: 10.1371/journal.pone.0023060

Figure 5. Effects of endogenous PTH deficiency and exogenous PTH on osteoclastic bone resorbtion in calluses at 2 and 4 weeks post-fracture.

Figure 5

Representative micrographs of sections of calluses from V-WT and V-KO mice and PTH-WT and PTH-KO mice at (A) 2 weeks and (B) 4 weeks post-fracture stained histochemically for TRAP. (C, D) Number of TRAP-positive osteoclasts related to tissue area (N.Oc/T.Ar, #/mm2) and (E, F) osteoclast surface relative to bone surface (Oc.S/BS, %) were assessed by computer-assisted image analysis. Each value is the mean ± SEM of determinations in 6 animals from each group. *, P<0.05; **, P<0.01 compared with WT mice of the same group. #, P<0.05; ##, P<0.01; ###, P<0.001 compared with genotype-matched V-treated mice.