. Author manuscript; available in PMC: 2012 Aug 15.

Published in final edited form as: Bioorg Med Chem Lett. 2011 Jun 22;21(16):4753–4757. doi: 10.1016/j.bmcl.2011.06.069

Table 1.

Sirtuin Inhibition^a

Compound		1	ThAcK^b	L-ACAH^c
IC₅₀ (μM)	SIRT1	89.5 ± 16.1	5.9 ± 1.6^d	290.0 ± 88.0^e
	SIRT2	159.1 ± 32.8	2.9 ± 1.3^d	190.2 ± 1.7^e
	SIRT3	57.2 ± 17.6	4.3 ± 0.1^d	213.5 ± 31.2^e

See ref. 63 for the SIRT1/2/3 inhibition assay details.

ThAcK, here referring to CH₃CONH-AcOrn-ThAcK-AcOrn-CONH₂.³⁷

L-ACAH, here referring to CH₃CONH-AcK-(L-ACAH)-AcK-CONH₂.³⁸

Taken from ref. 37.

Taken from ref. 38.