Table 1.
Clinico-pathological correlation of immunohistochemical expression of FASN in epithelial ovarian carcinomas.
| Total
|
High FAS-N
|
Low FAS-N
|
|||||
|---|---|---|---|---|---|---|---|
| Epithelial group | N | % | N | % | N | % | P value |
| Total number of cases | 151 | 114 | 75.5 | 37 | 24.5 | ||
| Age | |||||||
| ≤50 years | 59 | 39.1 | 46 | 78.0 | 13 | 22.0 | 0.5703 |
| >50 years | 92 | 60.9 | 68 | 73.9 | 24 | 26.1 | |
| Tumor Stage | |||||||
| Stage I-II | 8 | 5.7 | 6 | 75.0 | 2 | 25.0 | 0.9521 |
| Stage III-IV | 133 | 94.3 | 101 | 75.9 | 32 | 24.1 | |
| Histopathology | |||||||
| Clear cell | 4 | 2.6 | 3 | 75.0 | 1 | 25.0 | 0.4235 |
| Endometriod | 21 | 13.9 | 17 | 81.0 | 4 | 19.0 | |
| Serous | 122 | 80.8 | 90 | 73.8 | 32 | 26.2 | |
| Undifferentiated | 4 | 2.6 | 4 | 100.0 | 0 | 0.0 | |
| FIGO Grade | |||||||
| Well differentiated | 26 | 17.2 | 18 | 69.2 | 8 | 30.8 | 0.6596 |
| Moderately differentiated | 82 | 54.3 | 62 | 75.6 | 20 | 24.4 | |
| Poorly differentiated | 43 | 28.5 | 34 | 79.1 | 9 | 20.9 | |
| Ki-67 | |||||||
| Above 50 | 54 | 36.7 | 49 | 90.7 | 5 | 9.3 | 0.0009 |
| Below = 50 | 93 | 63.3 | 63 | 67.7 | 30 | 32.3 | |
| PAKT (Ser473) | |||||||
| High (2–3) | 75 | 52.4 | 64 | 85.3 | 11 | 14.7 | 0.0117 |
| Low (0–1) | 68 | 47.6 | 46 | 67.7 | 22 | 32.3 | |
| PFS-Median (months) | 17.7 | 12.3 | 0.1784 | ||||