Table 1.

Splice variants chosen for alternative splicing validation in TAV and BAV tissue samples.^a

Gene symbol	FN1	FN1	FN1	LTBP3
Probe set	2598304	2598321	2598356	3377684
Probe set location	FN1_E33 (EDA)	FN1_E25 (EDB)	FN1_E09	LTBP3_E19
TAV
Pb	0.0014	0.0012	0.9644	2.60E-05
Loading valuec	0.0694	0.0682	0.0062	0.0847
Jack-knife confidence intervald	0.0320	0.0328	0.0487	0.0348
ABS(loading) – ABS(jack-knife confidence interval)e	0.0373	0.0354	−0.0424	0.0499
ΔSI (D – C)f	0.7224	0.4288	0.0020	0.2242
BAV
Pb	0.2533	5.63E-05	0.5047	0.0026
Loading valuec	0.0192	0.0809	−0.0069	0.0630
Jack-knife confidence intervald	0.0512	0.0286	0.0639	0.0288
ABS(loading) – ABS(jack-knife confidence interval)e	−0.0320	0.0523	−0.0570	0.0341
ΔSI (D – C)f	0.1924	0.3565	−0.0208	0.1447

^aThe statistical analyses are based on controls (C) versus dilated (D) tissue samples. Values in bold indicate significant exons.

^bFDR-corrected t test.

^cLoading values from OPLS-DA multivariate model.

^dJack-knife confidence interval derived from cross-validation in OPLS-DA models.

^eSubtraction of the jack-knife confidence intervals from the corresponding loading values, if positive indicates significance.

^fDifference in average mean splice index between the groups indicated.