Table 2.
Levels of protein markers in striata of 2-year-old wild type, α-synuclein null mutant and γ-synuclein null mutant mice expressed as % of wildtype mean.
| Marker | Genotype |
||
|---|---|---|---|
| Wild type | α-Synuclein −/− | γ-Synuclein −/− | |
| TH | 100 ± 3.77 | 70.9 ± 8.09** | 98 ± 9.14 |
| DAT | 100 ± 8.74 | 63.2 ± 7.96* | 139.5 ± 11.32* |
| Amphiphysin | 100 ± 6.10 | 56.3 ± 12.24** | 94.6 ± 6.91 |
| Synaptotagmin | 100 ± 6.24 | 71.5 ± 9.96** | 96.5 ± 8.80 |
| Synaptophysin | 100 ± 5.28 | 104.8 ± 6.93 | 91.2 ± 5.09 |
| SNAP25 | 100 ± 8.79 | 97 ± 14.98 | 115 ± 7.72 |
| Rab3 | 100 ± 17.23 | 83.2 ± 13.62 | 117.5 ± 12.62 |
| Sec8 | 100 ± 7.20 | 86.6 ± 5.37 | 89.6 ± 14.52 |
| CSP | 100 ± 2.75 | 108.9 ± 7.37 | 109.3 ± 7.43 |
| GFAP | 100 ± 3.93 | 122.0 ± 9.09* | 122.7 ± 7.36* |
*
p < 0.05 and **p < 0.01, one-way ANOVA with post hoc Fisher’s protected t-test.