Table 2.
Predicted Risk of Breast Cancer in the General Population from Genetic Profiles
| Percentile | Lifetime Risk (95% CI) |
Incidence Rate Ratio (95% CI) |
10-Year-Risk at Age 50 (95% CI) |
Age at which 10-Year Risk > 2.39% |
Age at which 5-Year Risk > 1.66% | NNS |
|---|---|---|---|---|---|---|
| 5 | 0.057 (0.049–0.061) | 0.46 (0.39–0.49) | 0.011 (0.009–0.012) | NA | NA | 3913 |
| 10 | 0.068 (0.061–0.072) | 0.55 (0.49–0.58) | 0.013 (0.012-0.014) | NA | NA | 3265 |
| 20 | 0.084 (0.077–0.087) | 0.68 (0.63–0.71) | 0.016 (0.015–0.017) | 61.7 | NA | 2643 |
| 30 | 0.096 (0.091–0.099) | 0.79 (0.75–0.81) | 0.019 (0.018–0.019) | 55.9 | NA | 2281 |
| 40 | 0.108 (0.104–0.110) | 0.90 (0.86–0.91) | 0.021 (0.021–0.022) | 52.6 | 65.5 | 2018 |
| 50 | 0.120 (0.118–0.121) | 1.00 (0.98–1.01) | 0.024 (0.024–0.024) | 49.9 | 60.3 | 1805 |
| 60 | 0.133 (0.133–0.133) | 1.12 (1.12–1.12) | 0.027 (0.027–0.027) | 47.1 | 57.4 | 1619 |
| 70 | 0.148 (0.147–0.150) | 1.26 (1.25–1.28) | 0.030 (0.030–0.030) | 44.5 | 54.8 | 1445 |
| 80 | 0.167 (0.164–0.172) | 1.44 (1.41–1.49) | 0.034 (0.034–0.035) | 42.1 | 51.6 | 1269 |
| 90 | 0.195 (0.190–0.206) | 1.71 (1.67–1.82) | 0.041 (0.039–0.043) | 39.6 | 47.1 | 1067 |
| 95 | 0.221 (0.214–0.236) | 1.97 (1.90–2.14) | 0.047 (0.045–0.050) | 38.0 | 44.4 | 930 |
The percentile column refers to the percentile of the measurable liability derived from known susceptibility variants. The following abbreviations are used: CI, confidence interval; NNS, number of individuals that need to be screened in order to prevent one cancer death; NA, not applicable. Because of competing risks of mortality, the absolute risk will not reach the designated threshold in these groups of women. Also note that the incidence rate ratio is computed with reference to the general population.