Table 3.

Predicted Risk of Breast Cancer in Women Having One Affected First-Degree Relative from Genetic Profiles

Percentile	Lifetime Risk (95% CI)	Incidence Rate Ratio (95% CI)	10-Year-Risk at Age 50 (95% CI)	NNS	Age at which 10-Year Risk > 2.39%	Age at which 5-Year Risk > 1.66%
5	0.132 (0.119–0.138)	1.11 (0.99–1.17)	0.026 (0.024-0.028)	1634	47.3	57.6
10	0.150 (0.138–0.156)	1.28 (1.17–1.33)	0.030 (0.028-0.032)	1420	44.2	54.4
20	0.175 (0.165–0.179)	1.51 (1.43–1.55)	0.036 (0.034-0.037)	1206	41.3	50.3
30	0.194 (0.187–0.197)	1.70 (1.63–1.73)	0.040 (0.039-0.041)	1075	39.7	47.3
40	0.211 (0.207–0.213)	1.87 (1.83–1.89)	0.044 (0.043-0.045)	978	38.5	45.2
50	0.228 (0.226–0.229)	2.05 (2.03–2.06)	0.048 (0.048-0.048)	896	37.6	43.8
60	0.246 (0.245–0.246)	2.24 (2.23–2.25)	0.053 (0.052-0.053)	823	36.8	42.7
70	0.265 (0.263–0.269)	2.45 (2.43–2.50)	0.057 (0.057-0.059)	753	36.0	41.6
80	0.289 (0.286–0.297)	2.72 (2.68–2.82)	0.064 (0.063-0.066)	680	35.1	40.6
90	0.324 (0.318–0.338)	3.13 (3.06–3.31)	0.073 (0.071-0.077)	594	34.0	39.2
95	0.354 (0.345–0.374)	3.51 (3.40–3.77)	0.081 (0.079-0.087)	532	33.1	38.3

The incidence rate ratio is computed with reference to the general population. The following abbreviations are used: CI, confidence interval; NNS, number of individuals that need to be screened in order to prevent one cancer death.