Table 4.
Predicted Risk of Breast Cancer in Women Having One Affected First-Degree Relative, with Consideration of the Relative's Genotype Profile
| Percentile (Relative) | Percentile (Index Individual) | Lifetime Risk (95% CI) | Incidence Rate Ratio (95% CI) |
10-Year-Risk at Age 50 (95% CI) |
Age at which 10-Year Risk > 2.39% | Age at which 5-Year Risk > 1.66% |
|---|---|---|---|---|---|---|
| 5 | 5 | 0.141 (0.128–0.147) | 1.19 (1.07–1.25) | 0.028 (0.026–0.030) | 45.7 | 56.0 |
| 10 | 5 | 0.137 (0.124–0.143) | 1.16 (1.04–1.21) | 0.028 (0.025–0.029) | 46.4 | 56.7 |
| 30 | 5 | 0.129 (0.115–0.135) | 1.08 (0.96–1.14) | 0.026 (0.023–0.027) | 48.0 | 58.3 |
| 50 | 5 | 0.123 (0.110–0.130) | 1.03 (0.91–1.09) | 0.025 (0.022–0.026) | 49.2 | 59.5 |
| 70 | 5 | 0.118 (0.104–0.124) | 0.99 (0.86–1.04) | 0.024 (0.021–0.025) | 50.4 | 61.0 |
| 90 | 5 | 0.111 (0.097–0.117) | 0.92 (0.80–0.98) | 0.022 (0.019–0.023) | 52.0 | 63.8 |
| 95 | 5 | 0.107 (0.093–0.114) | 0.89 (0.77–0.95) | 0.021 (0.018–0.023) | 52.8 | 66.2 |
| 5 | 10 | 0.162 (0.151–0.167) | 1.39 (1.29–1.44) | 0.033 (0.031–0.034) | 42.6 | 52.3 |
| 10 | 10 | 0.158 (0.146–0.163) | 1.35 (1.25–1.40) | 0.032 (0.030–0.033) | 43.2 | 53.1 |
| 30 | 10 | 0.149 (0.137–0.154) | 1.27 (1.16–1.32) | 0.030 (0.028–0.031) | 44.4 | 54.6 |
| 50 | 10 | 0.143 (0.131–0.148) | 1.21 (1.10–1.26) | 0.029 (0.026–0.030) | 45.3 | 55.7 |
| 70 | 10 | 0.137 (0.125–0.143) | 1.16 (1.04–1.21) | 0.028 (0.025–0.029) | 46.3 | 56.7 |
| 90 | 10 | 0.129 (0.116–0.135) | 1.08 (0.97–1.14) | 0.026 (0.023–0.027) | 48.0 | 58.2 |
| 95 | 10 | 0.125 (0.112–0.131) | 1.05 (0.93–1.11) | 0.025 (0.022–0.026) | 48.8 | 59.1 |
| 5 | 90 | 0.366 (0.357–0.386) | 3.66 (3.54–3.93) | 0.085 (0.082–0.091) | 32.8 | 38.0 |
| 10 | 90 | 0.359 (0.350–0.378) | 3.57 (3.46–3.82) | 0.083 (0.080–0.088) | 33.0 | 38.2 |
| 30 | 90 | 0.345 (0.337–0.362) | 3.39 (3.30–3.61) | 0.079 (0.077–0.084) | 33.4 | 38.6 |
| 50 | 90 | 0.335 (0.328–0.351) | 3.27 (3.19–3.47) | 0.076 (0.074–0.080) | 33.6 | 38.9 |
| 70 | 90 | 0.326 (0.319–0.340) | 3.16 (3.08–3.33) | 0.073 (0.072–0.077) | 33.9 | 39.2 |
| 90 | 90 | 0.312 (0.307–0.325) | 2.99 (2.93–3.14) | 0.070 (0.068–0.073) | 34.3 | 39.7 |
| 95 | 90 | 0.306 (0.301–0.318) | 2.92 (2.86–3.06) | 0.068 (0.067–0.071) | 34.5 | 39.9 |
| 5 | 95 | 0.401 (0.389–0.426) | 4.13 (3.97–4.51) | 0.095 (0.091–0.103) | 32.0 | 37.1 |
| 10 | 95 | 0.394 (0.382–0.419) | 4.03 (3.88–4.39) | 0.093 (0.089–0.101) | 32.1 | 37.2 |
| 30 | 95 | 0.379 (0.369–0.402) | 3.84 (3.70–4.15) | 0.089 (0.086–0.095) | 32.5 | 37.6 |
| 50 | 95 | 0.369 (0.359–0.391) | 3.71 (3.58–4.00) | 0.086 (0.083–0.092) | 32.7 | 37.9 |
| 70 | 95 | 0.359 (0.350–0.380) | 3.58 (3.46–3.85) | 0.083 (0.080–0.089) | 33.0 | 38.1 |
| 90 | 95 | 0.345 (0.337–0.364) | 3.40 (3.30–3.63) | 0.079 (0.077–0.084) | 33.4 | 38.6 |
| 95 | 95 | 0.339 (0.331–0.356) | 3.31 (3.22–3.53) | 0.077 (0.075–0.082) | 33.5 | 38.8 |
CI is an abbreviation for confidence interval.