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. 2011 May 13;88(5):586–598. doi: 10.1016/j.ajhg.2011.04.014

Table 4.

False-Positive Rate of FE, RE, and the New RE at Thresholds of Increasing Significance

Threshold α FE RE New RE
0.05 4.98 × 10−2 (1.00) 3.75 × 10−2 (0.75) 4.98 × 10−2 (1.00)
1 × 10−2 9.94 × 10−3 (0.99) 7.03 × 10−3 (0.70) 9.93 × 10−3 (0.99)
1 × 10−3 9.90 × 10−4 (0.99) 6.67 × 10−4 (0.67) 9.88 × 10−4 (0.99)
1 × 10−4 9.78 × 10−5 (0.98) 6.36 × 10−5 (0.64) 9.80 × 10−5 (0.98)
1 × 10−5 1.03 × 10−5 (1.03) 6.65 × 10−6 (0.67) 1.02 × 10−5 (1.02)
1 × 10−6 9.20 × 10−7 (0.92) 5.70 × 10−7 (0.57) 8.90 × 10−7 (0.89)

The ratio between the false-positive rate and the threshold α is shown in the parentheses. The estimates are obtained from 100 million null panels. Five studies of equal sample size 1000 are assumed.