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. Author manuscript; available in PMC: 2011 Jul 30.
Published in final edited form as: Gastroenterology. 2009 Jun 21;137(3):795–814. doi: 10.1053/j.gastro.2009.06.040

Figure 1.

Figure 1

Schematic representation of the outcomes of HIV-1 and HCV infection. Persistent viruses such as HIV-1 and HCV achieve high levels of chronic viral replication. The ultimate outcomes of HIV-1 and HCV infection depend on host-viral interactions. (A) After initial HIV-1 infection, the viral set point can vary considerably and is related to the ultimate speed of progression to AIDS. About 5%–15% of individuals experience slow progression, while a very small subset of individuals are termed “elite controllers” of HIV-1. (B) After HCV infection, a subset is able to control the virus over a sustained period, termed “spontaneous clearance” or “spontaneous control,” but the majority (~50%– 80%) progress to chronic viremia.