Table 1.

Genes in the thioredoxin-mediated oxidative stress defense and angiogenesis pathway correlated with obesity

Symbol	Spearman's correlation (ρ)		P value		Gene name
	Min	Max	Min	Max
TXNRD1	0.646	0.655	<0.0001	<0.0001	Thioredoxin reductase 1
TXN	0.473	0.482	<0.0001	<0.0001	Thioredoxin
TXNDC9		0.368		<0.0001	Thioredoxin domain containing 9
TXNDC17		0.357		<0.0001	Thioredoxin domain containing 17
TXNIP		−0.328		<0.0001	Thioredoxin interacting protein
SRXN1		0.560		<0.0001	Sulfiredoxin 1
SULT1A2	0.458	0.525	<0.0001	<0.0001	Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SULT1A4	0.317	0.496	<0.0001	0.0002	Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
ANG	−0.603	−0.573	<0.0001	<0.0001	Angiogenin
VEGFA	−0.439	−0.421	<0.0001	<0.0001	Vascular endothelial growth factor A
TNMD		0.532		<0.0001	Tenomodulin
ANGPT1	0.440	0.494	<0.0001	<0.0001	Angiopoietin 1
ANGPT2	0.312	0.362	<0.0001	0.0002	Angiopoietin 2
RNH1	0.340	0.416	<0.0001	<0.0001	Ribonuclease/angiogenin inhibitor 1
AMOT		0.359		<0.0001	Angiomotin
MMP9		0.573		<0.0001	Matrix metallopeptidase 9
MMP28	0.357	0.463	<0.0001	<0.0001	Matrix metallopeptidase 28
NLRP3	0.440	0.456	<0.0001	<0.0001	NLR family, pyrin domain containing 3

Genes significantly correlated (Spearman's ρ ≥ 0.3, and P value <0.0001) with PFAT after adjusting for age, gender, and ethnicity in all nondiabetic subjects (n = 136) are shown. Correlation and significance of genes represented by multiple probes in the array are shown as minimum (min) and maximum (max) from Spearman's correlation analysis.