Figure 4.

LRP1 deletion leads to neurobehavioral abnormalities. A, B, Escape reflexes were tested in 13-month-old Cre⁺ and Cre⁻ mice (n = 8). Deletion of LRP1 decreases the latency to clasping of the hindlimbs. The latency was measured for up to 3 min. C, Rotarod performance is impaired in 18-month-old Cre⁺ mice. Each circle indicates the mean latency to fall on the accelerating rotarod (from 4 to 40 rpm over 5 min) (n = 8, both genotypes). D, Open field activity was tested in 18-month-old Cre⁺ and Cre⁻ mice (n = 8). Total distance traveled during 15 min in the open field. E, No difference in freezing was seen during the last minute of Fear Conditioning. F, G, Impaired cued and contextual fear memory in 18-month-old Cre⁺ mice 24 h after training (n = 8, both genotypes). H, LTP deficits in Cre⁺ mice. Brain slices were prepared from the hippocampus of 18-month-old Cre⁺ and Cre⁻ mice. Titanic used to evoke CA1 LTP consisted of two trains of 100 Hz stimulation for 1 s with each train separated by a 20 s interval. The data represent the means ± SEM. *p < 0.05.