Table 1.

Minimum inhibitory and minimum bactericidal concentrations in μg/ml of thymoquinone and tetracycline and their combination

	MIC TQ	MBC TQ	MIC TET	MBC TET	aMIC TET + 1/2MIC TQ	MBC TET + 1/2MIC TQ
References strains
Bacillus cereus ATCC 14579	8	8	2	8	0.5 (4)	4 (2)
Escherichia coli ATCC 35218	512	512	4	16	2 (2)	64 (4)
Enterococcus faecalis ATCC 29212	32	128	256	512	128 (2)	64 (8)
Salmonella enterica serovar Typhimurium ATCC 1408	256	512	128	256	32 (4)	128 (2)
Staphylococcus aureus ATCC 25923	8	16	4	8	0.5 (8)	4 (2)
Staphylococcus epidermidis CIP 106510	8	8	8	16	4 (2)	64 (4)
Listeria monocytogenes ATCC 19115	32	128	1	4	1 (NC)	4 (NC)
Micrococcus luteus NCIMB 8166	8	64	32	64	8 (4)	16 (4)
Pseudomonas aeruginosa ATCC 27853	>512	>512	64	128	32 (2)	256 (2)
Vibrio alginolyticus ATCC 33787	512	512	256	512	128 (2)	256 (2)
Vibrio paraheamolyticus ATCC 17802	32	64	4	32	0.5 (8)	8 (4)
Oral strains
E. faecalis B281	256	256	64	256	64 (NC)	128 (2)
Gemella haemolysans B234	128	128	512	256	256 (2)	256 (NC)
Staphylococcus aureus B73	256	256	64	128	16 (4)	16 (8)
Staphylococcus aureus B285	8	32	4	4	4 (NC)	8 (2)
Staphylococcus aureus B291	256	256	128	128	32 (4)	64 (2)
Staphylococcus aureus B289	16	16	4	4	<0.5 (>8)	2 (2)
Staphylococcus aureus B456	16	32	32	128	4 (8)	16 (8)
Staphylococcus aureus B244	16	32	32	32	4 (8)	8 (4)
Staphylococcus aureus B364	256	256	4	8	8 (2)	8 (NC)
Staphylococcus aureus B398	8	16	16	16	4 (4)	4 (4)
Streptococcus anginosus B486	64	64	128	256	64 (2)	128 (2)
Streptococcus constellatus B629	32	64	<0,5	4	<0.5 (NC)	4 (NC)
Streptococcus mitis B627	128	256	128	256	32 (4)	128 (2)
Streptococcus mutans B509	16	16	<0,5	8	<0.5 (NC)	4 (2)
Streptococcus oralis B634	32	64	128	128	32 (4)	64 (2)
Streptococcus salivarius B468	16	32	4	16	2 (2)	8 (2)

^aFold reductions are given in parentheses; NC, no change; TQ, thymoquinone; TET, Tetracycline