Table 1.
Subject characteristics of asthma (A) and healthy (H) subjects
| A | H | |||
|---|---|---|---|---|
| Total | HA | HNA | ||
| Subjects (n) | 8 | 8 | 5 | 3 |
| Male/Female (n) | 2/6 | 4/4 | 2/3 | 2/1 |
| Age (years)a | 24 (2) | 28 (10) | 30 (12) | 23 (2) |
| FEV1/FVC (%pred.)a,* | 96 (9) | 108 (7) | 105 (7) | 113 (4) |
|
Post-bronchodilator FEV1 (%pred.)a |
108 (11) | 115 (6) | 115 (6) | 114 (6) |
| Dose response slope (% decline FEV1/μmol methacholine)b,** | 6.49 (3.47-31.30) |
0.20 (0.04-0.30) |
0.23 (0.10-0.49) |
0.07 (0.03-0.23) |
Total = all healthy control subjects; HA = healthy, atopic; HNA = healthy, non-atopic
a Mean (SD)
b Median (P25-P75)
* A vs. Total p = 0.012; A vs. HNA p = 0.016
** A vs. Total p = 0.001; A vs. HA p = 0.003; A vs. HNA p = 0.014