Table 2.
Comparison of the activities of serum hepatic enzymes in the quartile water arsenic exposure groups by multivariate linear regression analyses
| Dependent variables | Independent variable (Water As) |
Before adjustment for covariates | After adjustment for covariatesb | ||||
|---|---|---|---|---|---|---|---|
| Coefficient (95% CI) | p-value (t-test) | R2 | Coefficient (95% CI) | p-value (t-test) | R2 | ||
| ALP | Lowest (0.11 - 24.7) |
- | - | 0.230 | - | - | 0.279 |
| Low (34 - 142) |
0.051 (0.005 - 0.097) |
< 0.05 | 0.039 (- 0.008 - 0.085) |
0.11 | |||
| Medium (145 - 242) |
0.082 (0.036 - 0.129) |
< 0.01 | 0.087 (0.041 - 0.134) |
< 0.01 | |||
| High (249 - 546) |
0.175 (0.129 - 0.222) |
< 0.01 | 0.165 (0.119 - 0.212) |
< 0.01 | |||
| AST | Lowest (0.11 - 24.7) |
- | - | 0.172 | - | - | 0.217 |
| Low (34 - 142) |
0.016 (-0.028 - 0.061) |
0.47 | 0.025 (- 0.020 - 0.070) |
0.27 | |||
| Medium (145 - 242) |
0.027 (- 0.018 - 0.071) |
0.24 | 0.023 (- 0.022 - 0.067) |
0.32 | |||
| High (249 - 546) |
0.13 (0.086 - 0.175) |
< 0.01 | 0.124 (0.080 - 0.169) |
< 0.01 | |||
| ALT | Lowest (0.11 - 24.7) |
- | - | 0.135 | - | - | 0.207 |
| Low (34 - 142) |
0.035 (- 0.037 - 0.107) |
0.34 | 0.060 (- 0.011 - 0.132) |
0.10 | |||
| Medium (145 - 242) |
0.085 (0.013 - 0.157) |
< 0.05 | 0.071 (0.00 - 0.143) |
0.05 | |||
| High (249 - 546) |
0.189 (0.117 - 0.261) |
< 0.01 | 0.186 (0.115 - 0.257) |
< 0.01 | |||
bAdjusted for age, sex, BMI, smoking habit and skin lesions; Log-transformed dependent and independent variables were used; Degrees of freedom (df) before and after adjustments were made for covariates, (3, 196) and (8, 191). Units of water arsenic, μg/L; ALP, AST and ALT activities, U/L.