Table 2.
Look AHEAD genotype frequencies of ANGPTL4 E40K and T266M by ethnic group
| ANGPTL4 variant | Genotype | Non-Hispanic White Americans | African American | Hispanic | P value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | % | MAF | n | % | MAF | n | % | MAF | p1 | p2 | p3 | ||
| E40K | 118 G > A | ||||||||||||
| EE | GG | 1868 | 95.8 | 418 | 99.8 | 129 | 95.6 | ||||||
| EK/KK | GA/AA | 82/0 | 4.2 | 0.021 | 1/0 | 0.2 | 0.001 | 5/1 | 4.4 | 0.027 | < 0.001 | 0.551 | < 0.001 |
| T266M | rs1044250 | ||||||||||||
| TT | CC | 961 | 48.1 | 242 | 56.0 | 63 | 45.0 | ||||||
| TM | CT | 845 | 42.2 | 164 | 34.0 | 61 | 43.6 | ||||||
| MM | TT | 194 | 9.7 | 0.31 | 26 | 6.0 | 0.25 | 16 | 11.4 | 0.33 | < 0.001 | 0.403 | 0.007 |
p1; Non-Hispanic whites vs. African Americans, p2; Non-Hispanic whites vs. Hispanics, p3; African Americans vs. Hispanics.