Table 3.
Association of E40K with baseline data in Non-Hispanic White Look AHEAD participants
| EE | EK | P value | |
|---|---|---|---|
| Mean (95% CI) | Mean (95% CI) | ||
| n males/n females | 934/934 | 40/42 | - |
| Triglycerides (mmol/L) | 1.94 (1.90, 1.99) | 1.61 (1.44, 1.80) | 0.001 |
| Cholesterol (mmol/L) | 4.86 (4.82, 4.90) | 4.88 (4.69, 5.08) | 0.889 |
| LDL-cholesterol (mmol/L) | 2.77 (2.73, 2.80) | 2.87 (2.70, 3.04) | 0.237 |
| HDL-cholesterol (mmol/L) | 1.05 (1.04, 1.06) | 1.10 (1.05, 1.16) | 0.081 |
| BMI (kg/m2) | 35.90 (35.87, 35.93) | 35.91 (35.78, 36.03) | 0.940 |
| Weight (kg) | 100.55 (100.21, 100.90) | 101.51 (99.88, 103.17) | 0.264 |
| Waist Circumference (cm) | 115.03 (114.69, 115.37) | 116.73 (115.11, 118.37) | 0.043 |
| Glucose (mmol/L) | 8.38 (8.28, 8.49) | 8.02 (7.56, 8.51) | 0.154 |
| HbA1c | 7.18 (7.14, 7.23) | 7.00 (6.79, 7.22) | 0.113 |
| SBP (mm/Hg) | 129.12 (128.31, 129.93) | 124.88 (121.23, 128.64) | 0.031 |
| DBP (mm/Hg) | 69.38 (68.98, 69.79) | 67.55 (65.71, 69.43) | 0.062 |
| Triglycerides (mmol/L) on subjects not receiving lipid lowering medication | 1.91 (1.85, 1.98) (n = 771) |
1.54 (1.31, 1.80) (n = 36) |
0.007 |
Data presented is mean (95% confidence intervals). Lipid data and blood pressure are adjusted for age, gender, study site, BMI, smoking, statins, diuretics, diabetes drugs, insulin, other lipid drugs, alcohol, menopause, HRT use. Anthropometric data are adjusted for age, gender, study site, smoking, statins, diuretics, diabetes drugs, insulin, other lipid drugs, alcohol, menopause, HRT use. Adjusted P values using a dominant model of inheritance are presented.