Table 4.
Association of T266M with baseline data in Non-Hispanic White Look AHEAD participants
| TT | TM | MM | P value | |
|---|---|---|---|---|
| Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | ||
| n males/n females | 461/500 | 428/417 | 93/101 | - |
| Triglycerides (mmol/L) | 1.99 (1.93, 2.06) | 1.87 (1.81, 1.94) | 1.75 (1.63, 1.89) | 0.002 |
| Cholesterol (mmol/L) | 4.91 (4.85, 4.96) | 4.84 (4.78, 4.90) | 4.79 (4.66, 4.91) | 0.120 |
| LDL-cholesterol (mmol/L) | 2.78 (2.73, 2.82) | 2.77 (2.72, 2.83) | 2.75 (2.65, 2.86) | 0.937 |
| HDL-cholesterol (mmol/L) | 1.05 (1.04, 1.07) | 1.05 (1.05, 1.12) | 1.09 (1.05, 1.12) | 0.178 |
| BMI (kg/m2) | 35.94 (35.90, 35.97) | 35.89 (35.85, 35.93) | 35.97 (35.89, 36.05) | 0.101 |
| Weight (lbs) | 100.71 (100.22, 101.19) | 100.31 (99.80, 100.83) | 101.10 (100.03, 102.18) | 0.331 |
| Waist Circumference (cm) | 115.08 (114.61, 115.55) | 114.91 (114.40, 115.41) | 115.77 (114.72, 116.82) | 0.346 |
| Glucose (mmol/L) | 8.44 (8.30, 8.59) | 8.32 (8.17, 8.47) | 8.19 (7.89, 8.51) | 0.269 |
| HbA1c | 7.22 (7.16, 7.29) | 7.13 (7.02, 7.20) | 7.08 (6.95, 7.23) | 0.067 |
| SBP (mm/Hg) | 129.18 (128.06, 130.30) | 128.68 (127.48, 129.88) | 126.85 (124.41, 129.34) | 0.243 |
| DBP (mm/Hg) | 69.45 (68.89, 70.01) | 69.15 (68.55, 69.76) | 68.43 (67.20, 69.68) | 0.327 |
|
Triglyceride (mmol/L) Following removal of E40K Carriers |
1.99 (1.92, 2.06) (n = 889) |
1.88 (1.81, 1.95) (n = 775) |
1.73 (1.60, 1.88) (n = 182) |
0.002 |
|
Triglycerides (mmol/L) Subjects not taking lipid-lowering medication |
1.95 (1.86, 2.05) (n = 416) |
1.82 (1.74, 1.93) (n = 344) |
1.66 (1.48, 1.85) (n = 75) |
0.01 |
Data presented is mean (95% confidence intervals). Lipid data and blood pressure are adjusted for age, gender, study site, BMI, smoking, statins, diuretics, diabetes drugs, insulin, other lipid drugs, alcohol, menopause, HRT use. Anthropometric data are adjusted for age, gender, study site, smoking, statins, diuretics, diabetes drugs, insulin, other lipid drugs, alcohol, menopause, HRT use. Adjusted P values using an additive model of inheritance are presented.