Skip to main content
. 2011 Jun 27;11:278. doi: 10.1186/1471-2407-11-278

Table 2.

Relationship between mutagen sensitivity and polymorphisms in unrelated subjects (n = 110)

Genetic Model Genotype Low High OR* 95% CI p
BRCA1 n = 44 % n = 66 %

E1038R Co-Dominant TT 20 18.2% 23 20.9% 1.00

CT 18 16.4% 32 29.1% 1.08 0.45 - 2.64

CC 6 5.5% 11 10.0% 1.07 0.32 - 3.60 0.46

Dominant CC/CT 24 21.8% 43 39.1% 1.60 0.47 - 2.47 0.34

Log-Additive 0.64 - 1.94 0.70

D693N Dominant CC 41 37.3% 57 51.8% 1.00

CT 1 0.9% 9 8.2% 6.03 0.69 - 52.02 0.10

Q356R Dominant TT 32 29.1% 56 50.9% 1.00

CT 11 10.0% 9 8.2% 0.57 0.20 - 1.60 0.28

Rad51 5' UTR 135G>C

Dominant GG 36 35.0% 35 34.0% 1.00

CC/CG 7 6.8% 25 24.3% 3.64 1.38 - 9.54 0.03

*Adjusted for age