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. 2011 Jul 19;11:303. doi: 10.1186/1471-2407-11-303

Table 1.

Leptin and VEGF enhance ES formation by HUVEC.

Conditions ES (%)
Untreated 100.0

Leptin 178.0 ± 3.0

Leptin + Aca1 10 nM 90.0 ± 1.0

Leptin + Aca1 25 nM 79.0 ± 6.5

Leptin + Aca1 50 nM 72.0 ± 32.5

Aca1 10 nM 103.5 ± 12.0

Aca1 25 nM 90.0 ± 1.0

Aca1 50 nM 68.0 ± 4.0

VEGF 160.0 ± 13.0

VEGF + SU1498 1 μM 121.0 ± 30.0

VEGF + SU1498 5 μM 98.0 ± 14.5

VEGF + SU1498 10 μM 73.0 ± 6.0

SU1498 1 μM 100.5 ± 23.0

SU1498 5 μM 91.0 ± 1.4

SU1498 10 μM 60.0 ± 10.0

ObR and VEGFR inhibitors counteract this effect.

Number of ES after treatment with 100 ng/mL leptin and/or Aca1Free 10, 25 and 50 nM or with 50 ng/mL VEGF and/or SU1498 1, 5 and 10 μM was scored as described in Materials and Methods. Untreated cells were taken as control (100%). Tube-like formation assay was performed for 8 h in VCBM. Means ± SD are shown.