Table 4.
Change in lung function parameters from pre-dose baseline to 2-h post-dose at week 12 in the full analysis set
| Parameter | Change from baseline, LS mean (95% CI) | |
|---|---|---|
| Fluticasone/formoterol | Fluticasone/salmeterol | |
| FVC (L) | 0.402 (0.296, 0.508) | 0.354 (0.247, 0.461) |
| MEF25 (%) | 15.3 (10.5, 20.2) | 17.3 (12.3, 22.3) |
| MEF50 (%) | 43.0 (33.1, 53.0) | 51.7 (41.5, 62.0) |
| MEF75 (%) | 87.8 (71.9, 103.6) | 93.5 (77.5, 109.5) |
FVC, forced vital capacity; LS, least-squares; MEF25; MEF50; MEF75, maximum expiratory flow rate at, respectively, 25%; 50%; and 75% of the volume to exhale.