Table 1E.
Hormonal agents in ischemic stroke
| Agent | Model | Dose/route | Time of administration | Species |
|---|---|---|---|---|
| Estrogen | MCAO | Acute: 1 mg/kg/IV Chronic: 25 or 100 μg |
Acute: 7-10 days before occlusion Chronic: 30 mins before occlusion |
Wistar rats [101]. |
| Hippocampal organotypic slice cultures |
0.5, 1, 5 nM | 48 hours before OGD exposure | Female Sprague Dawley rats P9-11 pups [102]. |
|
| Progesterone | MCAO | 8 mg/kg/IP 8 mg/kg additional doses/IV |
1 hour post occlusion Additional doses at 6, 24, and 48 hours post occlusion |
Sprague-Dawley rats [106]. |