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Combined agents in ischemic stroke
| Agent | Model | Dose/route | Time of administration | Species |
|---|---|---|---|---|
| Urokinase and topiramate |
Embolic MCAO | 2500 U Urokinase and 20 mg/kg Topiramate/IP |
2 hours after embolisation | Male Wistar rats [120]. |
| Ethyl pyruvate and aspirin |
MCAO | 5mg/kg Ethyl pyruvate and 5 mg/kg aspirin/IV |
1 hour after the occlusion | Sprague Dawley rats [121]. |
