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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Curr Opin Genet Dev. 2011 Apr 13;21(4):444–451. doi: 10.1016/j.gde.2011.03.002

Figure 1. T-cell receptor signaling pathways regulated by GREs.

Figure 1

The network diagram depicts the coordinate regulation of GRE-containing transcripts involved in T cell receptor signaling. Transcripts in bold are GRE-containing. Transcripts in grey were identified as CELF1 targets in HeLa cells by RNA-IP [43].

Transcripts in green represent short-lived GRE-containing transcripts expressed in primary human T cells [33], [37]. Transcripts labeled with an asterisk exhibited changes in steady state levels following T-cell receptor stimulation [33]. This network diagram was built using Ingenuity Pathway Assistant Software.