Table 3. Hazard ratios (95% CI) for chronic kidney disease associated with orthostatic hypotension among participants of the Atherosclerosis Risk in Communities study.

	Model 1† HR (95% CI)	Model 2* HR (95% CI)	Model 3† HR (95% CI)	Model 4‡
Number	12,507	11,542	8,325	11,662
OH present	1.67 (1.36, 2.06)	1.81(1.44, 2.27)	2.27 (1.57, 3.26)	1.67 (1.33, 2.09)
OH absent	1.00	1.00	1.00	1.00

P for interaction by race = 0.48

^†Adjusted for age, sex, race, resting systolic blood pressure, resting heart rate, type 2 diabetes, body mass index, current smoking and use of anti-hypertensive medications.

^*Excluding individuals taking other medications that can lower blood pressure (tricyclic antidepressant, benzodiazepines, phenothiazine and others, see Table 1) and adjusted for age, sex, race, resting systolic blood pressure, resting heart rate, type 2 diabetes, body mass index, current smoking, and use of anti-hypertensive medications

^†Excluding prevalent hypertensive individuals and adjusted for age, sex, race, resting systolic blood pressure, resting heart rate, type 2 diabetes, body mass index, and current smoking.

^‡Adjusting for age, sex, race, resting systolic blood pressure, resting heart rate, type 2 diabetes, body mass index, current smoking and use of anti-hypertensive medications and cIMT measures taken at visit 1.

OH=orthostatic hypotension; HR=hazard ratios; CI=confidence interval