Table 2.
Summary of 8 comparison studies.
| Study | Comparison name | Identified pathways |
|---|---|---|
| 1 | Intestine-CT (KO/WT) | PPARα-dependent pathway in intestine |
| 3 | Liver-CT (KO/WT) | PPARα-dependent pathway in liver |
| 2 | Intestine-WY (KO/WT) | WY14643 PPARα-dependent pathways in intestine |
| 4 | Liver-WY (KO/WT) | WY14643 PPARα-dependent pathways in liver |
| 5 | Intestine-WT (CT/WY) | WY14643-dependent pathways in intestine |
| 7 | Liver-WT (CT/WY) | WY14643-dependent pathways in liver |
| 6 | Intestine-KO (CT/WY) | PPARα-independent pathways in intestine |
| 8 | Liver-KO (CT/WY) | PPARα-independent pathways in liver |
There were 8 comparison studies related to PPARα in mice intestine or in liver included in our research. Each of the 8 comparisons identified dependent or independent pathways for PPARα or WY14643.
CT: mice were treated with normal food (control).
WY: mice were treated with the synthetic PPARα ligand WY14643 (0.1% w/w) mixed in the food.
KO: PPARα-null (129S4/SvJae) mice.
WT: wild type (129S1/SvImJ) mice.