Table 3.
The highly common down and up regulated pathways identified in studies of PPARα-dependent or independent effects both in liver and small intestine tissues of mice.
| Pathways | PPARα-dependent (KO/WT) | PPARα-independent (CT/WY) |
|---|---|---|
| Upregulated | 00511: other glycan degradation | 05322: systemic lupus erythematosus |
| 04142: lysosome | ||
| 04144: endocytosis | ||
| 04540: gap junction | ||
|
| ||
| Downregulated | 00071: fatty acid metabolism | 00010: glycolysis/Gluconeogenesis |
| 00380: tryptophan metabolism | 00071: fatty acid metabolism | |
| 00620: pyruvate metabolism | 00640: propanoate metabolism | |
| 00770: pantothenate and CoA biosynthesis | ||
| 01040: biosynthesis of unsaturated fatty acids | ||
| 03320: PPAR signaling pathway | ||
| 00410: beta-Alanine metabolism | ||
| 00561: glycerolipid metabolism | ||
There were 12 highly common pathways in comparisons of PPARα-dependent studies, including 4 upregulated and 8 downregulated pathways in both liver and small intestine of mice. The PPARα-dependent comparisons were made between PPARα null and wild type mice; By contrast, there were only 4 highly common pathways in comparisons of PPARα-independent studies, including 1 upregulated and 3 downregulated pathways in both liver and small intestine of mice. The comparisons were made between with normal food and with WY14643 treatment.