Table 3.
Correlation analyses of PON1 and PON3 expression and microsomal atorvastatin-lactone hydrolysis.
| PON1 protein | PON3 WT mRNA (exon 3–4) | PON3 VAR mRNA (exon 3a–4) | PON3 protein | Atorvastatin-acid formation | |
|---|---|---|---|---|---|
| rs = 0.45*** | rs = 0.42*** | rs = 0.40*** | n.s. | rs = 0.28*** | PON1 mRNA (exon 8–9) |
| rs = 0.27*** | rs = 0.28*** | rs = 0.48*** | rs = 0.60*** | PON1 protein | |
| rs = 0.90*** | rs = 0.31*** | rs = 0.33*** | PON3 WT mRNA (exon 3–4) | ||
| rs = 0.32*** | rs = 0.32*** | PON3 VAR mRNA (exon 3a–4) | |||
| rs = 0.62*** | PON3 protein |
*p < 0.05, **p < 0.01, ***p < 0.001.