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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2010 Dec 15;19(3):1298–1305. doi: 10.1016/j.bmc.2010.12.003

Table 1.

BaDHPS inhibition by the designed inhibitors

Structure % Inhibition Activity (without pre-incubation) % Inhibition Activity (with 10min pre-incubation*)
10 graphic file with name nihms259467t1.jpg 16.3@200μM 30.5@200μM
11 graphic file with name nihms259467t2.jpg 32.9@200μM 44.3@200μM
12 graphic file with name nihms259467t3.jpg 3.6@200μM 5.7@200μM
13 graphic file with name nihms259467t4.jpg 3.9@200μM 6.3@200μM
*

for pre-incubation, enzyme was incubated with inhibitor at 37°C for 10 min. Reaction was started by adding substrates.