Table 2.

Association of 17 genome-wide significant loci with CRP levels in the replication panel and combined with the discovery results

SNP	Coded allele	Replication		Discovery + replication		R-square**	P-value for heterogeneity	Closest Gene
		Beta*(SE)	P-value	Beta*(SE)	P-value
rs2794520	C	0.086 (0.010)	9.9×10−19	0.160 (0.006)	2.0×10−186	1.38	7.4×10−26	CRP
rs4420638	A	0.200 (0.032)	3.0×10−10	0.236 (0.009)	8.8×10−139	0.93	0.03	APOC1
rs1183910	G	0.122 (0.021)	8.3×10−14	0.149 (0.006)	2.1×10−124	0.76	0.08	HNF1A
rs4420065	C	0.045 (0.009)	1.5×10−6	0.090 (0.005)	3.5×10−62	0.39	1.1×10−9	LEPR
rs4129267	C	0.045 (0.010)	7.3×10−6	0.079 (0.005)	2.1×10−48	0.31	2.4×10−4	IL6R
rs1260326	T	0.031 (0.010)	1.9×10−3	0.072 (0.005)	4.6×10−40	0.24	2.6×10−6	GCKR
rs12239046	C	0.042 (0.018)	1.8×10−3	0.047 (0.006)	1.2×10−15	0.09	0.77	NLRP3
rs6734238	G	0.072 (0.017)	4.9×10−6	0.050 (0.006)	1.8×10−17	0.14	0.95	IL1F10
rs9987289	A	0.003 (0.031)	3.5×10−2	0.069 (0.011)	3.4×10−13	0.08	0.04	PPP1R3B
rs10745954	A	0.018 (0.015)	1.3×10−1	0.039 (0.006)	1.6×10−11	0.06	1.1×10−3	ASCL1
rs1800961	C	0.023 (0.026)	3.7×10−1	0.088 (0.015)	2.2×10−9	0.06	0.07	HNF4A
rs340029	T	0.004 (0.010)	5.2×10−1	0.032 (0.006)	4.1×10−9	0.08	0.05	RORA
rs10521222	C	0.089 (0.028)	1.4×10−3	0.104 (0.015)	8.5×10−13	0.09	0.34	SALL1
rs12037222	A	0.035 (0.017)	3.9×10−2	0.045 (0.007)	6.4 ×10−11	0.06	0.40	PABPC4
rs13233571	C	0.049 (0.025)	4.5×10−2	0.054 (0.009)	3.6 ×10−9	0.08	0.13	BCL7B
rs2836878	G	0.013 (0.011)	2.3×10−1	0.032 (0.006)	1.7 ×10−7	0.05	0.18	PSMG1
rs4903031	G	0.001 (0.012)	9.1×10−1	0.032 (0.007)	5.1 ×10−6	0.04	0.21	RGS6

^*Beta coefficient represents one unit change in the natural log transformed CRP (mg/L) per copy increment in the coded allele

^**Median percentage of CRP variance explained by the SNP reported in all participating studies