Table 3.
Association of three suggestive loci with CRP levels that reached genome-wide significance after combining discovery and replication panel
| SNP | Coded allele |
Discovery | Replication | Discovery + replication | R-square** | P-value for heterogeneity |
Closest Gene |
|||
|---|---|---|---|---|---|---|---|---|---|---|
| Beta*(SE) | P-value | Beta*(SE) | P-value | Beta*(SE) | P-value | |||||
| rs2847281 | A | 0.034 (0.007) | 1.7×10−7 | 0.018 (0.016) | 4.2×10−2 | 0.031 (0.006) | 2.2×10−8 | 0.04 | 0.97 | PTPN2 |
| rs6901250 | A | 0.034 (0.007) | 1.2×10−6 | 0.038 (0.015) | 1.2×10−2 | 0.035 (0.006) | 4.8×10−8 | 0.02 | 0.89 | GPRC6A |
| rs4705952 | G | 0.038 (0.008) | 4.1×10−6 | 0.065 (0.018) | 3.0×10−4 | 0.042 (0.007) | 1.3×10−8 | 0.05 | 0.47 | IRF1 |
*
Beta coefficient represents one unit change in the natural log transformed CRP (mg/L) per copy increment in the coded allele
**
Median percentage of CRP variance explained by the SNP reported in all participating studies