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. 2011 Jul 1;12(8):825–832. doi: 10.1038/embor.2011.111

Figure 4.

Figure 4

Ablation of Tb-Tim17 and Tb-mHsp70 does not affect mitochondrial ATP production or the membrane potential. Substrate-level phosphorylation and oxidative phosphorylation were determined in digitonin-isolated mitochondria of Tb-Tim17 (A) and Tb-mHsp70 (B) RNAi cell lines. The micrographs show Mitotracker-stained Tet-uninduced and Tet-induced, as well CCCP-treated cells. The percentage of membrane potential positive cells is indicated at the bottom. CCCP, carbonyl cyanide m-chlorophenylhydrazone; mHsp70, mitochondrial heat-shock protein 70; RNAi, RNA interference; Tet, tetracycline.