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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Mol Pharmacol. 2008 Sep 10;74(6):1544–1553. doi: 10.1124/mol.108.050435

Fig. 2.

Fig. 2

Transcriptional response to TCDD exposure in the developing jaw in zebrafish larvae. Zebrafish larvae (96 hpf) were exposed to TCDD (1 ng/ml) or vehicle (0.1% DMSO) for 1 h as described under Materials and Methods, and jaws were collected at 1, 2, 4, and 12 hpe (97, 98, 100, and 108 hpf) to be processed for microarray GeneChip expression analysis. The results of triplicate independent experiments are shown. Significant changes were determined by an unpaired t test, and transcripts significantly altered by TCDD by at least 2-fold (p < 0.05) compared with the DMSO control samples from the same time point are included in the heat map. Expression data were clustered using the SOM algorithm and depicted as a heat map where red is indicative of up-regulation and green is indicative of down-regulation.