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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Mol Pharmacol. 2008 Sep 10;74(6):1544–1553. doi: 10.1124/mol.108.050435

Fig. 8.

Fig. 8

Restoration of sox9b expression by sox9b mRNA injection partially rescues TCDD-induced jaw malformation in zebrafish embryos. Embryos were injected with 75 pg of sox9b mRNA or 75 pg of control mRNA at the 1–4 cell stage. These were then exposed to TCDD (1 ng/ml) for 1 h as described under Materials and Methods. Embryos were collected at 72 hpf for cartilage staining. Uninjected controls exposed to vehicle (0.1% DMSO) or TCDD (1 ng/ml) are shown for comparison. Three representative examples of sox9b mRNA injected embryos rescued from TCDD cartilage malformations are shown.