Table 1.
Effective protection induced by oral immunization with GK-1 using different delivery systemsa
| Group | Individual no. of cysticerci | Median no. (95% confidence limit) | % protection | % TpM |
|---|---|---|---|---|
| Nonimmunized | 88, 101, 91, 62, 71, 82, 100a | 88 (72–98) | 0 | |
| Immunized with priming/boost of: | ||||
| GK-1/GK-1 | 20, 23, 30, 35, 55, 19, 28b | 28 (19–41.5) | 64.7 | 0 |
| GK-1 + BLS/GK-1 | 6, 5, 5, 10, 0, 0, 0c | 5 (0.14–7.3) | 96.3 | 43 |
| GK-1-BLS/GK-1 | 16, 11, 15, 7, 0, 0, 0c | 7 (0.4–14) | 91.8 | 43 |
a
Cysticerci from 7 mice of each group were recovered 40 days after challenge. Different letters indicate the significant differences between parasite intensity using the Tukey-Kramer multiple-comparisons test (P < 0.001). No significant differences were noted between control and groups of totally protected mice according to Fisher's exact test (P > 0.05). TpM, totally protected mice.