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. 2011 Jul;18(7):1083–1090. doi: 10.1128/CVI.05075-11

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Fig. 3. — Histopathology on different mouse strains challenged with H1N1 PR8 virus with or without pretreatment with IgY to H5N1. (A and B) C.B-17 uninfected control; normal lungs. (C and D) C.B-17 mouse treated with IgY against H5N1 and challenged with 10⁴ TCID₅₀ PR8. (A and C) The lungs do not show any inflammatory lesions. (B and D) Intact bronchiolar mucosa and alveoli are visible. (E and F) C.B-17 mouse treated with control IgY and challenged with 10⁴ TCID₅₀ PR8. (E) Severe pulmonary inflammation. (F) The bronchiolar mucosa is damaged and infiltrated with leukocytes, predominantly polymorphs and macrophages. Leukocytes in the lumen and the peribronchial tissues are also visible. Magnifications, ×60 (A), ×240 (B), ×24 (C), ×240 (D), ×60 (E), and ×240 (F).