Table 4.
In vivo mouse trial showing a correlation between histopathology and PCR resultsa
| Mouse no. | Treatment group | Challenge dose (TCID50) | PCR result |
Histopathology result | |
|---|---|---|---|---|---|
| Lungs | Airways | ||||
| 1 | IgY to H5N1 | 104 | 0 | 0 | 0 |
| 2 | IgY to H5N1 | 106 | 0 | 0 | 0 |
| 3 | IgY to H5N1 | 106 | 0 | Positive | + |
| 4 | Control IgY | 104 | Positive | Positive | +++++ |
| 5 | Control IgY | 106 | Positive | Positive | +++++ |
| 6 | PBS | 104 | Positive | Positive | +++++ |
| 7 | PBS | 106 | Positive | Positive | +++++ |
a
Typical results for mice from the different groups used in the trial are represented. 0, no detectable virus by PCR and no histopathology; +, mild histopathology with perivascular infiltrates; +++++, severe histopathology with bronchopneumonia.