Fig. 1.

Temporal distribution of subject symptoms and HuNoV excretion. Open squares represent RT-PCR-detected HuNoV-positive stool samples collected from infected subjects during days 1 to 5 postchallenge while admitted to the GCRC and during weekly follow-up visits (days 8, 14, 21, 28, and 35 postchallenge). The distribution of squares (e.g., samples/follow-up visits) is the result of the sample collection time line and does not imply intermittent sample positivity or lack of sample positivity. All of the subjects, with the exception of one (11/12), completed all five follow-up visits and provided five stool specimens; one volunteer missed the day 8 follow-up appointment and provided four stool specimens. Filled diamonds represent self-reported and clinically assessed symptoms of infected subjects. The total number of infected subjects was 12 instead of 13 because one infected subject was not available for follow-up after day 8.