Table 3.
Major pathways and enzymes for carbon and nitrogen metabolism predicted from genomes
| Enzyme or pathwaya | Mt. mobilis JLW8 | Mt. versatilis 301 | Mv. glucosetrophus SIP3-4 | Mb. flagellatus KT | Methylophilales strain HTCC2181 |
|---|---|---|---|---|---|
| RuMP cycle | + | + | + | + | + |
| Gnd enzymes | GndB | GndB | GndA | GndA, GndB | GndA |
| MADH | + | − | − | + | − |
| NMG pathway | − | + | + | + | − |
| H4MPT pathway | + | + | + | + | − |
| H4F pathway | + | + | + | + | + |
| Fae homologs | Fae2 | Fae2, Fae3 | Fae2, Fae3 | Fae2, Fae3 | − |
| FDH2 | + | + | + | + | + |
| FDH4 | + | − | + | + | − |
| MDH (MxaFJGI) | − | − | + | + | − |
| PQQ synthesis | + | + | + | + | + |
| pqqA (gene copies) | 5 | 4 | 5 | 3 | 3 |
| MxaRSACKL copies | 2 | 2 | 3 | 3 | 2 |
| XoxF (copies) | 2 | 3 | 4 | 4 | 1 |
| NapA/NirBD | + | + | + | +b | − |
| AniA/Nor | + | − | − | − | − |
| Urea metabolism | − | + | + | + | − |
| Choline degradation | − | + | − | − | − |
| MCA cycle | + | + | − | − | + |
a
RuMP, ribulose monophosphate; Gnd, 6-phosphogluconate dehydrogenase; H4MPT, tetrahydromethanopterin; FDH, formate dehydrogenase, MDH, methanol dehydrogenase; MADH, methylamine dehydrogenase; NMG, N-methylglutamate; XoxF, homolog of the large subunit of methanol dehydrogenase; FDH, formate dehydrogenase; NapA/NirBD, assimilatory nitrate reduction pathway; AniA/Nor, denitrification pathway; MCA, methylcitric acid.
b
Nonorthologous.