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Tick immersion studies indicate the pdeB mutant is defective in the ability to colonize ticks and in the ability to transmit the infection from ticks to naïve mice
| Strain | % of fed ticks positive for B. burgdorferi | Mean no. of spirochetes/tick ± SD | No. of mice infected/total |
|---|---|---|---|
| Wild type | 88 | 3,366 ± 1,750 | 2/2 |
| pdeB mutant | 80 | 618 ± 837 | 0/4 |
| Complemented pdeB+ | 75 | 3,460 ± 1,975 | 2/2 |
