Table 2.
Clusters of genes with changes in expression common to lifted and adherent Ea.hy926 cells infected with p66+ versus Δp66 B. burgdorferi
| KEGG pathwaya | Lifted cellsb |
Adherent cellsb |
||
|---|---|---|---|---|
| No. of genes | P value | No. of genes | P value | |
| Focal adhesionc | 46 | 1.42E−09 | 10 | 4.89E−03 |
| Regulation of actin cytoskeleton | 39 | 5.77E−06 | 9 | 1.85E−02 |
| MAPK signaling pathwayc | 47 | 1.68E−05 | 15 | 3.1E−04 |
| Colorectal cancerc | 20 | 3.60E−05 | 7 | 1.01E−03 |
| Gliomac | 16 | 9.27E−05 | 4 | 3.38E−02 |
| Fc epsilon receptor I signaling pathway | 18 | 1.27E−04 | 7 | 6.85E−04 |
| VEGF signaling pathwayc | 16 | 5.27E−04 | 5 | 1.16E−02 |
| Natural killer cell-mediated cytotoxicityc | 23 | 6.28E−04 | 6 | 3.27E−02 |
| Jak-STAT signaling pathwayc | 26 | 7.65E−04 | 9 | 2.96E−03 |
| Chronic myeloid leukemiac | 16 | 8.66E−04 | 6 | 3.38E−03 |
| GnRH signaling pathwayc | 19 | 1.03E−03 | 5 | 4.12E−02 |
| Dorsoventral axis formation | 8 | 1.97E−03 | 3 | 1.41E−02 |
| Phosphatidylinositol signaling systemc | 14 | 4.33E−03 | 6 | 3.38E−03 |
| Pyrimidine metabolism | 16 | 8.16E−03 | 5 | 3.26E−02 |
| Sphingolipid metabolism | 8 | 1.64E−02 | 3 | 3.59E−02 |
| Alanine and aspartate metabolism | 7 | 2.22E−02 | 3 | 2.27E−02 |
| Inositol phosphate metabolismc | 9 | 2.51E−02 | 4 | 1.56E−02 |
| Cell cyclec | 17 | 2.95E−02 | 6 | 2.26E−02 |
| T cell receptor signaling pathwayc | 14 | 4.03E−02 | 5 | 3.53E−02 |
a
A complete list of KEGG pathways can be found at http://www.genome.jp/kegg/pathway.html.
b
P values considered to be statistically significant for lifted and adherent cells were <0.05 and <0.01, respectively, due to differences in the arrays used.
c
These pathways were also significantly different (P < 0.01) in lifted human microvascular endothelial cells (HMECs) infected with p66+ B. burgdorferi versus Δp66 B. burgdorferi.