Table 4.

Clusters of genes with changes in expression common to lifted and adherent 293 and 293+α_vβ₃ cells infected with p66⁺ versus Δp66 B. burgdorferi^a

Cell	KEGG pathwayb	Lifted cellsc		Adherent cellsc
		No. of genes	P value	No. of genes	P value
293	NAd	NA	NA	NA	NA
293+αvβ3	Cell communication	3	0.0384	5	3.68E−02
	Pathogenic Escherichia coli infection (EHEC)	2	0.0362	3	4.39E−02
	Pathogenic Escherichia coli infection (EPEC)	2	0.0362	3	4.39E−02

^aHuman kidney epithelial line HEK 293 (293 cells) and a derivative transfected to express the genes for the integrin α_v and β₃ subunits (293+α_vβ₃ cells) were examined.

^bKEGG pathways listed at http://www.genome.jp/kegg/pathway.html. EHEC, enterohemorrhagic Escherichia coli; enteropathogenic EPEC, Escherichia coli.

^cP values considered to be statistically significant for lifted and adherent cells were <0.05 and < 0.01, respectively, due to differences in the arrays used.

^dNA, not applicable. There were no pathways significantly differentially affected by infection with p66⁺ versus Δp66 B. burgdorferi in both adherent and lifted cells.