Survival of mice passively immunized with antibody to PMA or PMA-FLA. (A) Mice challenged with P. aeruginosa type a strain PAK (≈5 × 107 CFU/mouse; log-rank test: PMA-FLA versus PMA, P = 0.021; PMA-FLA versus NRS, P = 0.0141; PMA versus NRS, P = 0.6714; median survival: PMA-FLA, undefined; PMA or NRS, 48 h). (B) Mice challenged with P. aeruginosa type a strain N13 (≈1.27 × 107 CFU/mouse; log-rank test: PMA-FLA versus PMA, P = 0.0034; PMA-FLA versus NRS, P = 0.0024; PMA versus NRS, P = 0.9349; median survival: PMA-FLA, 30 h; PMA or NRS, 12 h). (C) Mice challenged with P. aeruginosa type a strain N6 (≈2.66 × 107 CFU/mouse; log-rank test: PMA-FLA versus PMA, P = 0.0293; PMA-FLA versus NRS, P = 0.4009; PMA versus NRS, P = 0.2330; median survival: PMA-FLA and NRS, undefined; PMA, 48 h). (D) Mice challenged with P. aeruginosa type b strain PAO1 ExoU+ (≈5 × 107 CFU/mouse; log-rank test: PMA-FLA versus PMA, P = 0.0062; PMA-FLA versus NRS, P = 0.0168; PMA versus NRS, P = 0.6980; median survival: undefined for either group).